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KMID : 0525720190240020105
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Journal of Chitin and Chitosan
2019 Volume.24 No. 2 p.105 ~ p.109
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Formation of Glycol chitosan-phycocyanin Microparticles by Ionic Interactionand the Effect of Singlet Oxygen Generation
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Kim Min-Ah
Kim Jin
Lee Chang-Moon
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Abstract
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In this study, we investigated the microparticle formation of glycol chitosan (GC) and C-phycocyanin (CPC), which can be used for photodynamic therapy, through electrostatic interaction. The mean particle size of the GC-CPC microparticles was 360.2 ± 4.1 nm and was spherical. The DPBF analysis showed that the GC-CPC microparticles produced singlet oxygen effectively after 635 nm laser irradiation at 80 mW/cm2 for 5 min. The results indicate that the GC-CPC microparticles did not lose their photodynamic characteristics even after ion complex formation. Therefore, it is expected that the GC-CPC ionic microparticles proposed in this study can be applied to photodynamic therapy.
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KEYWORD
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Glycol chitosan, C-phycocyanin, Photodynamic therapy, Ionic complex, Microparticles
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